New research suggests that people who discontinue popular weight-loss injections like semaglutide or tirzepatide may regain shed pounds far faster than those who stop traditional diet and exercise plans.
Published data in a leading medical journal shows that while obese people frequently drop substantial amounts of their body weight while on the medication, the mass returns at an estimated rate of 0.8 kg per month upon discontinuation.
"People using such drugs must be cognizant of the danger of quick weight regain when the treatment is stopped," cautioned lead investigator Dr. Susan Jebb.
That rate of regain implies a reversion to starting weight in about 18 months.
Weighing Treatments
The analysis, which reviewed 37 of studies involving over 9,000 of patients, compared the effects of the injectable medications with other pills.
The team emphasize that individuals who lose weight through diet and exercise generally see a more gradual creep back—perhaps 0.1 kg a month—after stopping.
The Reason for the Rapid Regain
Experts propose the mode of action of the injections is key to understanding the accelerated rebound.
GLP-1 drugs imitate a natural hormone called glucagon-like peptide-1, which moderates hunger.
"Artificially providing the hormone levels far above than the body's typical production may cause the body to generate a reduced amount of its own natural hormone, and may also diminish sensitivity to its actions," explained Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this medication means hunger is no longer kept in check, making binge eating far more likely."
An Ongoing Issue?
Medical guidelines advise the jabs for individuals with weight-linked medical conditions, alongside prescribed diet and exercise modifications.
A number of clinicians argue that, due to the significant potential of relapse, the therapy might need to be life-long.
This perspective is supported by drug manufacturers, who state that the results "highlight the long-term character of obesity," comparing it to managing conditions like diabetes.
User Accounts
Users who have stopped the jabs explain a powerful return of cravings.
"It felt as if a switch activating and you're instantly extremely hungry," described a patient.
The struggle is worsened if patients have not developed sustainable lifestyle or habit modifications during treatment.
Widespread Adoption
Survey data suggest that a significant number of people in the UK have tried weight-loss jabs in the past year, with demand remaining high.
- Adoption is greater among females compared to men.
- The 40s and 50s demographic shows the highest level of interest.
- Many access the drugs through private healthcare rather than the NHS.
In conclusion, researchers emphasize that while the jabs are powerful agents for weight loss, they are not a standalone cure and maintained weight loss relies on ongoing behavioural support.
